Glycochemistry - Principles, Synthesis and Applications

696 pages, Illustrated  ISBN 0824705386      £120.00

US, Canadian, and Chinese chemists summarize recent research into the synthesis, principles, and applications of carbohydrates for graduate students and researchers in carbohydrate chemistry, biochemistry, medicinal chemistry, and glycobiology. The topics include solid phase oligosaccharide synthesis, the chemical synthesis of bioactive steroidal saponins, the chemistry and biology of multi-valent saccharide displays, structures and mechanisms of action of aminoglycoside antibiotics, synthesizing glycosaminoglycans, glycosyltransferases in oligosaccharide synthesis, and metabolic substrate engineering as a tool for glycobiology Glycochemistry: Principles, Synthesis, and Applications presents methods used in the development of carbohydrate-based therapeutics. It highlights applications in chemical and enzymatic synthesis of complex carbohydrates, carbohydrate function, and carbohydrate-mediated biological recognition processes. There are practical examples on the development of carbohydrate-based pharmaceuticals and polymers for commercial use. The text also emphasizes the role of carbohydrates as key elements in modern molecular recognition processes.

Contents

• Introduction - New Challenges in Carbohydrate Research
• Solid Phase Oligosaccharide Synthesis
• Dehydrative Glycosylation with 1-Hydroxy Donors
• Chemistry of Clycosyl Triflates - Synthesis of Beta-Mannopyranosides
• C-Glycoside Synthesis - Recent Developments and Current Trends
• D-Arabinofuranosides from Mycobacteria - Synthesis and Conformation
• Chemical Synthesis of Bioactive Steroidal Saponins
• Recent Developments in Technology for Clycosylation with Sialic Acid
• The Chemistry and Biology of Multivalent Saccharide Displays
• Designing Novel Multivalent Blycotools for Biochemical Investigations Related to Sialic Acid Aminoglycoside Antibiotics - Structures and Mechanisms of Action
• Methodologies in Syntheses of Aminoglycoside Antibiotics
• Synthesis of Glycoaminoglycans
• Pyranosyl Sugar Amino Acid Conjugates - Their Biological Origins, Synthetic Preparations, and Structural Characterization
• Glycosyltransferases in Oligosaccharide Synthesis
• Biotransformation of Polysaccharides
• From a Carbohydrate Sequence to Extensive Research Programmes - A Case Study
• Microbial Glycosyltransferases
• Metabolic Substrate Engineering as a Tool for Glycobiology