Topical Absorption of Dermatological Products

544 pages, Illustrated  ISBN 0824706269      £125.00

• novel treatments for fungal nail infections
• emerging risk assessment procedures for sunscreen products
• real-time breath analysis and physiologically based pharmacokinetic modeling (PBPK) for the examination of chemically exposed tissues
• the use of micelles, mixed micelles, liposomes, and microemulsions as effective drug delivery systems
• modern therapeutic devices for the management of acute, subacute, and chronic steroid-responsive dermatoses

Contents

Mechanisms of Absorption
Cutaneous Metabolism During In Vitro Percutaneous Absorption, Robert L. Bronaugh, Margaret E. K. Kraeling, Jeffrey J. Yourick, and Harolyn L. Hood
Occlusion Does Not Uniformly Enhance Penetration In Vivo, Daniel A. W. Bucks and Howard I. Maibach
Regional Variation in Percutaneous Absorption, Ronald C. Wester and Howard I. Maibach
The Development of Skin Barrier Function in the Neonate, Lourdes B. Nonato, Yogeshvar N. Kalia, Aarti Naik, Carolyn H. Lund, and Richard H. Guy
Cutaneous Metabolism of Xenobiotics, Saqib J. Bashir and Howard I. Maibach
Percutaneous Drug Delivery to the Hair Follicle, Andrea C. Lauer
In Vivo Relationship Between Percutaneous Absorption and Transepidermal Water Loss, André Rougier, Claire Lotte, and Howard I. Maibach
Dermal Decontamination and Percutaneous Absorption, Ronald C. Wester and Howard I. Maibach

Methodology
In Vivo Methods for Percutaneous Absorption Measurement, Ronald C. Wester and Howard I. Maibach
Determination of Percutaneous Absorption by In Vitro Techniques, Robert L. Bronaugh, Harolyn L. Hood, Margaret E. K. Kraeling, and Jeffrey J. Yourick
Systemic Absorption of Cutaneous Material, Robert L. Bronaugh and Harolyn L. Hood
Interrelationships in the Dose-Response of Percutaneous Absorption, Ronald C. Wester and Howard I. Maibach
Effect of Single Versus Multiple Dosing in Percutaneous Absorption, Ronald C. Wester and Howard I. Maibach
Blood Flow as a Technology in Percutaneous Absorption: The Assessment of the Cutaneous Microcirculation by Laser Doppler and Photoplethysmographic Techniques, Ethel Tur
Drug Concentration in the Skin, Christian Surber, Eric W. Smith, Fabian P. Schwarb, Tatiana Tassopoulos, and Howard I. Maibach
Stripping Method for Measuring Percutaneous Absorption In Vivo, André Rougier, Didier Dupuis, Claire Lotte, and Howard I. Maibach
Interference with Stratum Corneum Lipid Biogenesis: An Approach to Enhance Transdermal Drug Delivery, Peter M. Elias, Vivien Mak, Carl Thornfeldt, and Kenneth R. Feingold
Methods for the Assessment of Topical Corticosteroid-Induced Skin Blanching, John M. Haigh, Eric W. Smith, Carryn H. Purdon, and Howard I. Maibach
Importance of In Vitro Release Measurement in Topical Dermatological Dosage Forms, Vinod P. Shah, Jerome S. Elkins, and Roger L. Williams
Innovative Methods to Determine Percutaneous Absorption in Humans: Real-Time Breath Analysis and Physiologically Based Pharmacokinetic Modeling, Karla D. Thrall, Torka S. Poet, Richard A. Corley, Howard I. Maibach, and Ronald C. Wester
Calculations of Body Exposure from Percutaneous Absorption Data, Richard H. Guy and Howard I. Maibach

Drug and Cosmetic Absorption
Percutaneous Penetration as a Method of Delivery to Skin and Underlying Tissues, Parminder Singh
Phonophoresis, Joseph Kost, Samir Mitragotri, and Robert Langer
Facilitated Transdermal Delivery by Iontophoresis, Parminder Singh, Puchun Liu, and Steven M. Dinh
Percutaneous Penetration as It Relates to the Safety Evaluation of Cosmetic Ingredients, Jeffrey J. Yourick and Robert L. Bronaugh
Percutaneous Absorption of Fragrances , Jeffrey J. Yourick, Harolyn L. Hood, and Robert L. Bronaugh
Hair Dye Absorption, Leszek J. Wolfram
Percutaneous Absorption of Alpha-Hydroxy Acids, Margaret E. K. Kraeling and Robert L. Bronaugh
Optimizing Patch Test Delivery: A Model, Ronald C. Wester and Howard I. Maibach
Nail Penetration: Focus on Topical Delivery of Antifungal Drugs for Onychomycosis Treatment, Ying Sun, Jue-Chen Liu, Jonas C. T. Wang, and Piet De Doncker
Topical Dermatological Vehicles: A Holistic Approach, Eric W. Smith, Christian Surber, Tatiana Tassopoulos, and Howard I. Maibach
Percutaneous Absorption of Sunscreens, Kenneth A. Walters and Michael S. Roberts
Colloidal Drug Carrier Systems, Konstanze Jahn, Annett Krause, Martin Janich, and Reinhard H. H. Neubert
Alternative Therapies-Calling Up the Reserves: A Topical Nonsteroidal Formulary for the Management of Acute, Subacute, and Chronic Steroid-Responsive Dermatoses and Other Skin Afflictions, Jerome Z. Litt
Ointments, Creams, and Lotions Used as Topical Drug Delivery Vehicles, Christian Surber, Tatiana Tassopoulos, and Eric W. Smith
Index