Mitochondria

Comb bound  600 pages  ISBN 0125612850      £56.95

This book, volume 65 in the series Methods in Cell Biology, discusses mitochondria, the organelle that produces energy within living cells and contributes to the biosynthesis of key compounds including building blocks for proteins, nucleic acids, hormones and lipids. New evidence has illustrated that mitochondria also play critical rolls in neurodegenerative diseases, programmed cell death, and aging. This volume covers mitochondrial structure, function and biogenesis providing biochemical, cell biological and genetic approaches to the subject. It is organized in a convenient bench-top format and is full of step-by-step "how to" methods with sample results and suggestions of how these may be interpreted, including information on possible pitfalls making it of value to researchers in cell biology in academia as well as those in pharmaceutical and biotechnology companies and private research facilities. Other key features include a unique set of appendices that include coverage of gene catalogs, mtDNA maps and reagents for probing respiratory chain function. It also covers applications of state-of-the art microarray and gene chip technologies.