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Bioinformatics - Tools and Applications
Edited by Edwards, David; Stajich, Jason; Hansen, David
Springer
September 2009
Hardcover 451 pp ISBN 9780387927374
£59.00
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Biology has progressed tremendously in the last decade due in part to the increased automation in the
generation of data from sequences to genotypes to phenotypes. Biology is now very much an information
science and bioinformatics provides the means to connect biological data to hypotheses. Bioinformatics: Tools
and Applications provides up-to-date descriptions of the various areas of applied bioinformatics, from the
analysis of sequence, literature, and functional data to the function and evolution of organisms. The ability to
process and interpret large volumes of data is essential with the application of new high throughput DNA
sequencers providing an overload of sequence data. Initial chapters provide an introduction to the analysis
of DNA and protein sequences, from motif detection to gene prediction and annotation, with specific chapters
on DNA and protein databases as well as data visualization.
Additional chapters focus on gene expression
analysis from the perspective of traditional microarrays and more recent sequence based approaches,
followed by an introduction to the evolving field of phenomics, with specific chapters detailing advances in
plant and microbial phenome analysis and a chapter dealing with the important issue of standards for functional
genomics.
Further chapters present the area of literature databases and associated mining tools which
are becoming increasingly essential to interpret the vast volume of published biological information,
while the final chapters present bioinformatics purely from a developers point of view, describing
the various data and databases as well as common programming languages used for bioinformatics applications.
These chapters provide an introduction and motivation to further avenues for implementation. Together,
this volume aims to provide a resource for biology students wanting a greater understanding of the
encroaching area of bioinformatics, as well as computer scientists who are interested learning more
about the field of applied bioinformatics.
Written for: Graduate level students in biology, plant/animal sciences researchers, libraries, scientists
working in the field of plant and animal sciences
Contents
- Introduction.
- DNA sequence databases.
- Sequence comparison tools.
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Genome browsers.
- Small RNA analysis.
- Gene prediction methods.
- Gene annotation methods
- Regulatory motif analysis.
- Molecular Marker Discovery and Genetic map Visualisation.
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Sequence based gene expression analysis.
- Protein sequence databases.
- Protein structure prediction
- Proteome studies.
- Plant phenome data analysis.
- Phenome analysis of microorganisms.
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Standards for Functional Genomics.
- Literature databases.
- Advanced literature mining tools
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Data and databases.
- Programming languages
- Index
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