Biological Inorganic Chemistry - An introduction

Hardcover  382 pp  ISBN 9780444527400      £55.00

• Relaxed and agreeable writing style. The reader will not only fiind the book easy to read, the fascinating anecdotes and footnotes will give him pegs to hang important ideas on.
• Written by a biochemist. Will enable the reader to more readily grasp the biological and clinical relevance of the subject.
• Many colour illustrations. Enables easier visualization of molecular mechanisms
• Written by a single author. Ensures homgeneity of style and effective cross referencing between chapters

The importance of metals in biology, the environment and medicine has become increasingly evident over the last twenty five years. The study of the multiple roles of metal ions in biological systems, the rapidly expanding interface between inorganic chemistry and biology constitutes the subject called Biological Inorganic Chemistry. The present text, written by a biochemist, with a long career experience in the field (particularly iron and copper) presents an introduction to this exciting and dynamic field.

The book begins with introductory chapters, which together constitute an overview of the concepts, both chemical and biological, which are required to equip the reader for the detailed analysis which follows. Pathways of metal assimilation, storage and transport, as well as metal homeostasis are dealt with next.

Thereafter, indivbidual chapters discuss the roles of sodium and potassium, magnesium, calcium, zinc, iron, copper, nickel and cobalt, manganese, and finlly molybdenum, vanadium, tungsten and chromium.

The final three chapers provide a tantalising view of the roles of metals in brain function, biomineralization and a brief illustration of their importance in both medicine and the environment.

Of interest to students: Chemists / biologists following courses in Inorganic biochemistry / Bioinorganic chemistry. Chemistry, biology, medicine, environmental sciences Researcher: Because it is clearly written and gives a homogeneous view of the subject Chemistry, biology, microbiology, plant science, medical research (preclinical and clinical) environmental research Consultant: To have access to important informations collected in one volume. Pharmacological industry, foodstuffs and agro-industries, environmental applications

Contents

• The role of metals in biology - an overview
• Basic coordination chemistry for biologists
• Structural and molecular biology for chemists
• Biological ligands for metal ions
• An overview of intermediary metabolism and bioenergetics
• Methods which can be used to study metals in biology
• Metal assimilation pathways
• Transport, storage and homeostasis of metal ions
• Sodium and potassium
• Calcium Magnesium Zinc Iron Copper Nickel and cobalt
• Manganese Molybdenum, vanadium, tungsten and chromium
• Metals in brain function
• Biomineralisation
• Metals in medicine and the environment
• Concluding remarks