New Enzymes for Organic Synthesis: Screening, Supply and Engineering

Softcover  235 pages  ISBN 3540655492      £35.00

Isolated enzymes are of value in the synthesis of complex molecules with more and more applications emerging every year. This book described in six reviews the various steps in the development of enzymatic syntheses for useful compounds,. Three of the papers cover topics such as screening of novel enzymes, biochemical characterisation and engineering approaches used in order to increase the performance of various reactions. Then the use of protein design as a tool for the directed improvement of reactivity and selectivity of biocatalysts is described in two reviews. The last review considers the ways in which sufficient quantities of biocatalysts may be made available, covering fluidized bed adsorption as an emerging technology for the simple and fast purification of biomolecules and its potential in the large scale production of enzyme based catalysts. The chapter headings for these reviews are as follows:

• Optimizing industrial enzymes by directed evolution.
• Protein design on pyruvate decarboxylase (pdc) by site-directed mutagenesis.
• Screening of novel microbial enzymes for the production of biologically and chemically useful compounds.
• Glycobiotechnology: enzymes for the synthesis of nucleotide sugars.
• New alcohol dehydrogenases for the synthesis of chiral compounds.
• Fluidized bed adsorption as a primary recovery step in protein purification.

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Springer : biochemistry : biological conversion : biotechnology : chemistry : chiral compounds : enzymology : evolution : genetics : microbiology : protein engineering : proteins : sucrose & sugar crops