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Systems Biology
Edited by Mohamed Al-Rubeai and Martin Fussenegger
Springer
January 2007
Hardcover 425 pp ISBN 9781402052514
£107.00
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A comprehensive guide to the revolutionary area of systems biology and its application in cell
culture engineering, this volume presents an overall picture of the current topics central to structural
and functional genomics, proteomics, metabolomics and bioinformatics, including such hot topics as
RNAi, metabolic engineering and unfolded protein response.
It includes reviews of the cellular resp
onse of environmental modulation such as low temperature and osmolarity, critical assessments
of the applications of metablomics and fluxomics approaches, examination of the utility of modulation
of key genes and a presentation of a theory of chemical organisation which provides new view on the
system's structure.
The clearly written chapters by experts in the field describe methods applicable to investigating the
unique facets of cell culture. The book should be of interest to all those working in cell culture
development and drug discovery in pharmaceutical and biotechnology companies as well as in
academic institutions.
It provides an invaluable resource for students and researchers in biotechnology,
cell culture, genomics and bioinformatics.
Written for university and Research Institutes libraries, Senior and postgraduate researchers,
researchers in Systems Biology, Genomics, Proteomics, Bioinformatics, Animal Cell Culture,
Metabolomics and Metabolic Engineering, Biopharmaceutical Industry
Contents
List of Contributors.
- Structural Genomics: a Special Emphasis on Membrane Proteins.
- RNA Interference in Haematopoietic and Leukaemic Cells.
- Genomics and Proteomics of Chinese Hamster Ovary (CHO) Cells: Understanding
- CHO Cell Culture at the Molecular Level.
- The Unfolded Protein Response
- Engineering of Cell Proliferation via MYC Modulation
- The Molecular Response(s) During Cellular Adaption To and Recovery From, Sub-Physiological
Temperatures
- Molecular Respinse to Osmotic Shock.
- Metabolomics: an Emerging Tool For Understanding Metabolic Systems.
- Metabolic Flux Analysis of Mammalian Cells.
- Metabolic Engineering
- Chemical Organisation Theory
- Systems Biology of Prokaryotic Organisms.
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