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Sphingolipid Biology
Edited by Hirabayashi, Yoshio; Igarashi, Yasuyuki; Merrill, Alfred H. Jr.
Springer
August 2006
hardcover 304 p., 50 illus. ISBN 4431341986
£165.00
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Sphingolipids are fundamental to the structures of cell membranes, lipoproteins, and the stratum cornea of the skin.
Many complex sphingolipids as well as simpler sphingoid bases and derivatives are highly bioactive as extra-
and intracellular regulators of growth, differentiation, migration, survival, senescence, and numerous cellular
responses to stress. This book provides many examples of exciting new developments in sphingolipid biology/
sphingolipidology that are changing our understanding of how multicellular organisms grow, develop, function,
age, and die. Key areas addressed include sphingolipid biosynthesis, transport and membrane organization/lipid
rafts; genetic approaches to understanding the roles of membrane sphingolipid biosynthesis; sphingolipid metabolism,
specific G protein-coupled receptors (GPCRs), and signal transduction; and sphingolipid-associated disease and
drug development.
Of interest to lipid researchers and scientists in related disciplines.
Contents
Part 1: Overview.
- Sphingolipids Synthesis, Transport and Cellular Signaling Serine Palmitoyltransferase.
Part 2: Biosynthesis, Transport of Sphingolipids. - Serine Palmitoyltransferase.
- Ceramide Synthase.
Dihydroceramide: Sphinganine D 4-Desaturase and C4-Hydroxylase.
- Metabolizing Enzymes Such
As Sphingomyelin Synthase Induce Cell Death by Increasing Ceramide Content.
- Glucosylceramide
and Galactosylceramide Synthase.
- Synthesis, Metabolism, and Trans-Bilayer Movement of
Long-Chain Base.
- Molecular Mechanism of Ceramide Trafficking from the Endoplasmic
Reticulum to the Golgi Apparatus in Mammalian Cells.
- Sphingolipid Trafficking.
-
Current Perspectives on Saccharomyces cerevisiae Sphingolipids.
Part 3: Generation and Degradation of Sphingolipid Signaling Molecules. - Generation
of Signaling Molecules by de novo Sphingolipid Synthesis.
- Overview of Acid and
Neutral Sphingomyelinases in Cell Signaling
- Neutral Ceramidase as an Integral Modulator
for the Generation of S1P and S1P-Mediated Signaling.
- Activation of Sphingosine Kinase
1.- Ceramide 1-Phosphate.
- Sphingosine-1-Phosphate Lyase.
Part 4: Membrane Domain and Biological Function. - Close Interrelationship of Sphingomyelinase
and Caveolin in Triton X-100-Insoluble Membrane Microdomains.
- Roles of Membrane Domains
in the Signaling Pathway for B Cell Survival
- The Role of Lipid Rafts in Axon Growth and Guidance.
- Sphingolipids and Multidrug Resistance of Cancer Cells.
Part 5: Membrane Lipid Domain and Human
Pathobiology. - A New Pathological Feature of Insulin Resistance and Type
2 Diadetes: Involvement of Ganglioside GM3 and Membrane Microdomains.
-
Neuronal Cell Death in Glycosphingolipidoses
- Endocytic Trafficking
of Glycosphingolipids in Sphingolipidoses.
- Ganglioside and Alzheimer€s
To find similar publications, click on a keyword below:
Springer
: biochemicals
: biochemistry
: biology, general
: biomedical sciences
: lipids
: membranes
: physiology
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