Computational Systems Biology

Hardback  424 pp      £75.00

Contents

• Introducing Computational Systems Biology. A Kriete and R Eils

I. Enabling Information and Integration Technologies for Systems Biology:

• Databases for Systems Biology. J Eils, C Lawerenz, K Astrahantseff, M Ginkel, and R Eils
• Natural Language Processing and Ontology-enhanced Biomedical Literature Mining for Systems Biology. X Hu
• Integrated Imaging Informatics. B Parvin, G Fontenay, Q Yang, and MH Barcellos-Hoff
• Simpathica: A Computational Systems Biology Tool within the Valis Bioinformatics Environment. B Mishra, M Antoniotti, S Paxia and N Ugel
• Standards, Platforms and Applications. HM Sauro

II. Foundations of Biochemical Network Analysis and Modeling

• Introduction to Computational Models of Biochemical Reaction Networks. FJ Bruggeman, BM Bakker, JJ Hornberg, and HV Westerhoff
• Biological Foundations of Signal Transduction and the Systems Biology Perspective. U Klingmüller
• Reconstruction of Metabolic Network from Genome Information and Its Structural and Functional Analysis. H-W Ma and A-P Zeng
• Integrated Regulatory and Metabolic Models. M.W. Covert

III. Computer Simulations of Dynamic Networks

• A Discrete Approach to Network Modeling. R Laubenbacher and P Mendes
• Gene Networks: Estimation, Modeling and Simulation. S Imoto, H Matsuno, and S Miyano
• Computational models for circadian rhythms: Deterministic versus stochastic approaches. J-C Leloup, D Gonze, and A Goldbeter

IV. Multi-Scale Representations of Cells and Emerging Phenotypes

• Multistability and Multicellularity: Cell Fates as High-dimensional Attractors of Gene Regulatory Networks. S Huang
• Spatio-Temporal Systems Biology. A Ghosh, D Miller, R Zou, B Sokhansanj,and A Kriete
• Cytomics€from cell states to predictive medicine. G Valet, RF Murphy, JP Robinson, A Tárnok, A Kriete
• The IUPS Physiome Project: Progress and Plans. P Hunter, K Burrowes, J Fernandez, P Nielsen, N Smith, and M Tawhai

Subject Index