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The Comprehensive Sourcebook of Bacterial Protein Toxins - 3rd edition
Edited by Joseph Alouf and Michel Popoff
Academic Press
December 2005
Hardback 1072 pages ISBN 0120884453
£125.00
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- Edited by two of the most highly regarded experts in the field from the Institut Pasteur, France
- 14 brand new chapters dedicated to coverage of historical and general aspects of toxinology
- Includes the major toxins of both basic and clinical interest are described in depth
- Details applied aspects of toxins such as therapy, vaccinology, and toolkits in cell biology
- Evolutionary and functional aspects of bacterial toxins evaluated and summarized
- Toxin applications in cell biology presented
- Therapy (cancer therapy, dystonias) discussed
- Vaccines (native and genetically engineered vaccines) featured
- Toxins discussed as biological weapons, comprising chapters on anthrax, diphtheria, ricin etc.
Bacterial toxins play an important role in infectious diseases. Several are amongst the most potent biological
agents known to man. Cholera, pertussis, botulinum, clostridium and tetanus toxins are all produced by bacteria.
In many cases, it is the toxin produced and not the infectious agent itself that causes pathology. Botulinum toxin
has now of course found clinical application as botox, and anthrax, and other toxins, have potentially devastating
effects if misused as an agent of biological terror. This book describes the major achievements and discoveries
relevant to bacterial protein toxins since the turn of the new century, illustrated by the discovery of more than
fifty novel toxins (many of them identified through genome screening). The establishment of the three-dimensional
crystal structure of more than 20 toxins during the same period offers deeper knowledge of structure-activity
relationships and provides a framework to understand how toxins recognize receptors, penetrate membranes and
interact with and modify intracellular substrates.
Of interest to Researchers, Academics, Graduate Students and PhD's in general microbiology, clinical microbiology and infectious disease
Contents
- Introduction
- A 116-year story of bacterial protein toxins (1888-2004): From diphtheritic poison to molecular toxinology
- Evolutionary aspects of toxin-producing bacteria
- Mobile genetic elements and pathogenicity islands encoding bacterial toxins
- Regulation systems of toxin expression
- Toxin secretion systems
- Intracellular trafficking of bacterial protein toxins
- Translocation of bacterial protein toxin into the cytosol
- Bacterial toxins and virulence factors targeting the actin cytoskeleton and
intracellular junctions
- Bacterial toxins and mitochondria
- Toxins activating RHO GTPases and exploiting the cellular ubiquitin/proteasome
machineries
- Toxin receptors
- Molecular, functional and evolutionary aspects of ADP-ribosylating toxins
- Diphtheria toxin
- Attack of the nervous system by clostridial toxins: Physical findings, cellular and
molecular actions
- Uptake and transport of clostridial neurotoxins
- Bacillus anthracis toxins
- Large clostridial cytotoxins modifying small GTPases
- Bordetella protein toxins
- Vibrio Cholerae and Escherichia Coli thermolabile enterotoxin
- The Shiga toxins: Properties and action on cells
- Helicobacter pylori vacuolating toxin
- Pasteurella multocida toxin
- Cytolethal distending toxins
- Pseudomonas aeruginosa toxins
- Escherichia coli heat- stable enterotoxin b
- Paradigms and classification of bacterial membrane -damaging toxins
- Membrane damaging and cytotoxic phospholipases
- Bacteroides fragilis toxins
- Structure and mode of action of RTX cytolysins
- Genetics and phylogeny of RTX cytolysins
- The family of two-component cytolysins of Serratia and other
bacteria
- Alpha-helix and Beta-barrel pore-forming toxins (leucocidins, alpha-, gamma- and
delta-cytolysins) of Staphylococcus aureus
- Aerolysin and related Aeromonas toxins
- Clostridium septicum pore-forming alpha-toxin
- Clostridium perfringens epsilon toxin
- Repertoire and general features of the family of cholesterol€dependent cytolysins
- Comparative three-dimensional structure of cholesterol-dependent cytolysins
- Perfringolysin O and Intermedilysin: mechanisms of pore formation by the
- cholesterol-dependent cytolysins
- Pneumolysin: structure, function and role in disease
- Listeriolysin
- Enterococcus faecalis cytolysin toxin
- Streptolysin S: one of the most potent and elusive of all bacterial toxins
- The group B streptococcal beta-haemolysin/cytolysin
- Haemolysins of Vibrio cholerae and other Vibrio species
- Clostridium perfringens enterotoxin
- Bacillus cereus enterotoxins, bi- and tri-component cytolysins and other
haemolysins
- Uropathogenic Escherichia coli cytolysins
Escherichia coli, Vibrio and Yersinia species heat-stable enterotoxins
What are superantigens ?
Staphylococcal superantigens and the diseases they cause
- Streptococcal superantigenic toxins
- Superantigenic toxin of Yersinia pseudotuberculosis
- Comparative three-dimensional structure of bacterial superantigenic toxins
- Induction and modulation of inflammatory networks by bacterial protein toxins
- Clostridial toxins in the pathogenesis of gas gangrene
- Staphylococcal exfoliative toxins
- Medical applications of botulinum neurotoxins
- Bacterial protein toxins as food poisons
- Engineering of bacterial toxins for research and medicine
- Engineered bacterial toxin vaccines and adjuvants
- Toxins as tools
- Bacterial protein toxins as biological weapons
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