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DNA Conformation and Transcription
Edited by Takashi Ohyama
Springer
2005
Hardcover XII, 211 p. 63 illus., 23 in colour ISBN 0387255796
£92.00
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Despite remarkable progress in genome science, we are still far from a clear understanding of how genomic DNA
is packaged without entanglement into a nucleus, how genes are wrapped up in chromatin, how chromatin structure
is faithfully inherited from mother to daughter cells, and how the differential expression of genes is enabled in a given
cell type. Exploring and answering these questions constitutes one of the next frontiers in the 21st century.
We are just beginning to appreciate how Multifarious DNA structures provide additional structural and functional
dimensions to chromatin organization and gene expression. DNA Conformation and Transcription is the first book
that compiles the fruits of the studies that have been performed to date to solve the riddle 'written' in DNA
conformation ("conformation code"). This book provides a comprehensive overview of the field by covering
history of the field, up-to-date topics, clarifications of present day research, and future perspective of what is
still to be discovered. Thus, it serves as an invaluable source of information on the "conformation code".
Written for: Researchers in the fields of Molecular Biology, Molecular Genetics, Biochemistry, Bioinformatics,
and Cell Biology and is accesible to specialists and non-specialtists alike, graduate students in various departments
including Molecular Biology, Genetics, Biochemistry, Cell Biology, Molecular Science, Chemistry, and Biophysics
Contents
- DNA: alternative conformations and biology.
- Sequence-specific variations in helix conformation
and their biological importance.
- Curved DNA and prokaryotic promoter function: a mechanism
of transcriptional activation.
- Repression of transcription by curved DNA and nucleoid protein H-NS: a
mode of bacterial gene regulation.
- Curved DNA and eukaryotic transcription.
- Putative roles of kin17, a mammalian protein binding curved DNA, in transcription.
- Roles for Z-DNA and double-stranded RNA in transcription: encoding genetic information
by shape rather than by sequence.
- Do DNA triple helices or quadruplexes have a role in transcription?.
- Nucleic acid structures and the transcription defects in Fragile X syndrome and Friedreich€s ataxia.
- Possible roles of DNA supercoiling in transcription
- Gene regulation by HMG1, 2, I/Y and related architectural DNA-binding proteins.
- Molecular mechanisms of male sex determination: the enigma of SRY.
- Unusual DNA, chromatin structure, and transcription.
- DNA bendability and nucleosome positioning in transcriptional regulation.
To find similar publications, click on a keyword below:
DNA
: RNA
: Springer
: molecular biology
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