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Free-Radical-Induced DNA Damage and Its Repair
Clemens von Sonntag
Springer
November 2005
Hardcover 530, 13 ills ISBN 3540261206
£176.00
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Understanding of the molecular basis of DNA damage and its repair has increased dramatically in recent years,
and substantial knowledge now exists concerning the products arising from free-radical attack on DNA.
Free-radical DNA damage may lead to mutations, cancer, and cell death. Free radicals have various sources,
notably ionizing radiation and oxidative stress. In radiotherapy for cancer and with some anticancer drugs, use
is made of cell death by excessive DNA damage. The mechanisms leading to products of free-radical attack
which have been studied in models and with small double-stranded DNA fragments are discussed in detail, and
the basics of the underlying free-radical chemistry are dealt with in separate chapters.
Written for Libraries, institutes, scientists
Contents
Introduction.
Formation of Reactive Free-radicals in an Aqueous Environment.
The Hydroxyl Radical.
Hydrogen Atom and Hydrated Electron.
Inorganic Radicals.
Carbon-Centered Radicals.
Heteroatom-Centered Radicals.
Peroxyl Radicals.-Polymer Radicals.
Nucleobases, Nucleosides and Nucleotides.
Polynucleotides and Single-Stranded DNA Fragments.
DNA and Double-Stranded Oligonucleotides.Methods
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