|
|
|
Allostasis, Homeostasis, and the Costs of Physiological Adaptation
Edited by Jay Schulkin
CUP
January 2005
Hardback 384 pages ISBN 0521811414
£65.00
|
|
|
|
|
|
The concept of homeostasis, the maintenance of the internal physiological environment of an organism
within tolerable limits, is well established in medicine and physiology. In contrast, allostasis is a relatively
new idea of 'viability through change'. With allostatic regulation by cephalic involvement, the body adapts
to potentially diverse and dangerous situations through the activation of neural, hormonal, or immunological
mechanisms. Allostasis explains how regulatory events maintain organismic viability, or not, in diverse contexts
with varying set points of bodily needs and competing motivations. This book introduces the concept of allostasis
and sets it alongside traditional views of homeostasis. It addresses basic regulatory systems and examines the
behavior of bodily regulation under duress. The basic concepts of physiological homeostasis are integrated with
disorders like depression, stress, anxiety and addiction. It will therefore appeal to graduate students, medical
students and researchers working in physiology, epidemiology, endocrinology, neuroendocrinology, neuroscience,
and psychology.
- The first edited volume to address the concept of allostasis
- Introduces the relatively new concept of allostasis while placing it alongside the more established idea of
homeostasis
- Integrates the concepts of physiological homeostasis with disorders like depression, stress, anxiety, and addiction
Contents- 1. Principles of allostasis: optimal design, predictive regulation, pathophysiology and
rational therapeutics Peter Sterling;
- 2. Protection and damaging effects of the mediators of stress and adaptation:
allostasis and allostatic load Bruce S. McEwen;
- 3. Merging of the homeostatic theory with the concept
of allostatic load David S. Goldstein;
- 4. Operationalizing allostatic load Burton Singer, Carol D.
Ryff and Teresa Seeman;
- 5. Drug addiction and allostasis George F. Koob and Michael LeMoal;
- 6. Adaptive fear and the pathology of anxiety and depression: an allostatic framework Jeffrey B.
Rosen and Jay Schulkin;
- 7. A chronobiological perspective on allostasis and its application to shift
work Ziad Boulos and Alan M. Rosenwasser;
- 8. Allostatic load and life cycles: implications for neuroendocrine
control mechanisms John C. Wingfield;
- 9. Commentary: viability as opposed to stability: an evolutionary
perspective on physiological regulation Michael L. Power.
To find similar publications, click on a keyword below:
Cambridge University Press
: animal science
: physiology
|
|
|
|
