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DNA Microarrays and Gene Expression
Pierre Baldi and G. Wesley Hatfield
CUP
September 2002
Hardback 230 pages ISBN 0521800226
£35.00
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Massive data acquisition technologies, such as genome sequencing, high-throughput drug screening,
and DNA arrays are in the process of revolutionizing biology and medicine. Using the mRNA of a given
cell, at a given time, under a given set of conditions, DNA microarrays can provide a snapshot of the level
of expression of all the genes in the cell. Such snapshots can be used to study fundamental biological phenomena
such as development or evolution, to determine the function of new genes, to infer the role individual genes
or groups of genes may play in diseases, and to monitor the effect of drugs and other compounds on gene
expression. This inter-disciplinary introduction to DNA arrays will be essential reading for both biology and
computer science researchers wanting to take advantage of this powerful new technology.
- Concise, user-friendly overview of this revolutionary new technology
- Co-authored by a computer scientist and biologist to give a unique, inter-disciplinary introduction to this
fast-moving field
- An accessible introduction for both the biology and computer science communities
Contents
- Preface;
- 1. A brief history of genomics;
- 2. DNA array formats;
- 3. DNA array readout methods;
- 4. Gene expression profiling experiments: problems, pitfalls and solutions;
- 5. Statistical analysis of array data: inferring changes;
- 6. Statistical analysis of array data: dimensionality reduction, clustering, and regulatory regions;
- 7. Survey of current DNA array applications;
- 8. Systems biology: overview of regulatory, metabolic and signaling networks.
To find similar publications, click on a keyword below:
Cambridge University Press
: DNA
: cell biology
: genes
: microarrays
: signalling
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