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Life As a Matter of Fat - The Emerging Science of Lipidomics
Ole G. Mouritsen
Springer
Hardcover XIV + 276 p ISBN 3540232486
£38.50
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Published as one of the series The Frontiers Collection this book introduces lipidomics, the science of fats.
Lipids are as important for life as proteins, sugars, and genes. The present book presents a multidisciplinary
perspective on the physics of life and the particular role played by lipids and the lipidbilayer component of
cell membranes. The book is aimed at undergraduate students and young research workers within physics,
chemistry, biochemistry, molecular biology, nutrition, as well as pharmaceutical and biomedical sciences.
The emphasis is on the physical properties of lipid membranes seen as soft and molecularly structured interfaces.
By combining and synthesizing insights obtained from a variety of recent studies, an attempt is made to clarify what
membrane structure is and how it can be quantitatively described. Furthermore, it is shown how biological
function mediated by membranes is controlled by lipid membrane structure and organization on length s
cales ranging from the size of the individual molecule, across molecular assemblies of proteins and lipid domains
in the range of nanometers, to the size of whole cells. Applications of lipids in nanotechnology and biomedicine are
also described.
A scientific revolution at the end of the 20th century introduced the genomics era with a focus on sequencing genes
and mapping gene products. This has been followed by the proteomics era where the multitude of proteins that
are encoded in the genes are identified and their functions are unveiled. In front of us we have a new era
recognizing the role of lipids. The science of lipidomics is emerging. Lipidomics involves a quantitative experimental
and theoretical study of, e.g. lipid and membrane selfassembly, lipidprotein interactions, lipidgene interactions,
and the biophysical properties of lipid structure, function, and dynamics.
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