Peptides: Chemistry and Biology

Hardcover  XXXIV, 563 Pages  ISBN 3527304053      £85.00

A compact introduction to modern peptide research and a comprehensive reference in one volume. This unique volume covers all the relevant chemical and biological aspects of this wide-ranging field in a concise and easily comprehensible manner. These include the physiological importance, structure, analysis, synthesis, peptide libraries and peptide design. Specialists and experts in particular will profit from the first-class encyclopedic appendix with data on more than 500 physiologically active peptides and proteins.

From the contents

INTRODUCTION AND BACKGROUND

FUNDAMENTAL CHEMICAL AND STRUCTURAL PRINCIPLES Definitions and main conformational features of the peptide bond
Building blocks, classification and nomenclature
Analysis of the covalent structure of peptides and proteins
Three-dimensional structure
Methods of structural analysis

BIOLOGICALLY ACTIVE PEPTIDES
Occurrence and biological roles
Biosynthesis
Selected bioactive peptide families

PEPTIDE SYNTHESIS
Principles and objectives
Protection of functional groups
Peptide bond formation
Racemization during synthesis
Solid phase peptide synthesis (SPPS)
Biochemical synthesis

SYNTHESIS CONCEPTS FOR PEPTIDES AND PROTEINS
Strategy and tactics
Synthesis in solution
Optimized strategies on polymeric support
Ligation of unprotected peptide segments

SYNTHESIS OF SPECIAL PEPTIDES AND PEPTIDE CONJUGATES
Cyclopeptides
Cystine peptides
Glycopeptides
Phosphopeptides
Lipopeptides
Sulfated peptides

PEPTIDE AND PROTEIN DESIGN, PSEUDOPEPTIDES, PEPTIDOMIMETICS
Peptide design
Modified peptides
Peptidomimetics
Pseudobiopolymers
Macropeptides and de novo design of peptides and proteins

COMBINATORIAL SYNTHESIS
Parallel synthesis
Synthesis of mixtures

APPLICATION OF PEPTIDES AND PROTEINS
Protein pharmaceuticals
Large scale peptide synthesis
Peptide pharmaceuticals
Peptide drugs and new drug assays