St. John's Wort and Its Active Principles in Depression and Anxiety

Hardcover  188 pp  ISBN 3764361603      £91.00

Hypericum extract preparations are used extensively in many countries to treat mildly to moderately depressed patients. While this was based previously on traditional experience, extensive research over the last ten years has given a broad preclinical and clinical basis to justify the use of Hypericum as an antidepressant. The book reviews the actual data related to the biochemical, functional, and behavioural pharmacology of Hypericum and its active constituents. The clinical chapters overview the evidenced basis for its use as an antidepressant, initial data in anxiety and somatoform disorders, and the site effect profile of Hypericum and its possible relevant drug interactions. A final chapter deals with the known pharmacokinetics of the relevant constituents and with the biopharmaceutical quality of commercially available Hypericum preparations.