Molecular Biology of the Gene (International Edition) - 6th Edition

Paperback  880 pages  ISBN 9780321507815      £58.00

Please note: This title is not available from CPL Press in North America or Australasia - please contact a local source

The classic textbook in molecular biology, updated with new chapters, new information, and new media.

• Early chapters on chemical and molecular interactions emphasize the importance of the strong chemical bonds that hold molecules together and the weak bonds that mediate interactions between them - the basis for how life works.
• Balanced coverage of prokaryotic and eukaryotic systems.
• Important experiments and techniques relevant to chapter concepts are explained in depth in boxes in every chapter. These include recent techniques from the fields of genomics and bioinformatics.

Completely up-to-date with the latest research advances, the Sixth Edition of James D. Watson€s classic text, Molecular Biology of the Gene retains the distinctive character of earlier editions that has made it the most widely used book in molecular biology. Twenty-two concise chapters, co-authored by six highly respected biologists, provide current, authoritative coverage of an exciting, fast-changing discipline.

Two new chapters discuss the emerging research fields of Regulatory RNAs (Chapter 18) and Genomics and Systems Biology (Chapter 20), and give particular focus on RNAi, microRNAs, the opportunities offered by the new generation of genome technologies, and the elucidation of gene regulatory networks.

Every chapter includes thorough content updates, and where relevant, the inclusion of medical insights that have emerged from our understanding of basic molecular biology, and references that direct students to explore the expanded companion website.

Contents

PART 1 Chemistry and Genetics 1 Mendelian View of the World
2 Nucleic Acids Convey Genetic Information
3 The Importance of Weak Chemical Interactions
4 The Importance of High Energy Bonds
5 Weak and Strong Bonds Determine Macromolecular Interactions

PART 2 Maintenance of the Genome
6 The Structures of DNA and RNA
7 Genome Structure, Chromatin and the Nucleosome
8 DNA replication
9 The Mutability and Repair of DNA
10 Homologous Recombination at the Molecular Level
11 Site-Specific Recombination and Transposition of DNA

PART 3 Expression of the Genome
12 Mechanisms of Transcription
13 Splicing
14 Translation

PART 4 Regulation
15 The Genetic Code
16 Transcriptional Regulation in Prokaryotes
17 Transcriptional Regulation in Eukaryotes
18 Regulatory RNAs
19 Gene Regulation in Development and Evolution
20 Genomics and Systems Biology

PART 5 Methods
21 Techniques of Molecular Biology
22 Model Organisms