|
|
|
Restriction Endonucleases (2004)
Edited by Pingoud, Alfred
Springer
2004
Hardcover 400 pp, 100 illus, 16 tabs ISBN 3540205020
£169.00
|
|
|
|
|
|
Restriction enzymes are highly specific nucleases which occur ubiquitously
prokaryotic organisms, where they serve to protect bacterial cells against foreign DNA.
Many different types of restriction enzymes are known, among them multi-subunit enzymes
which depend on ATP or GTP hydrolysis for target site location. The best known
representatives, the orthodox type II restriction endonucleases, are homodimers which
recognize palindromic sequences, 4 to 8 base pairs in length, and cleave the DNA within
or immediately adjacent to the recognition site. In addition to their important biological role
(up to 10 % of the genomes of prokaryotic organisms code for restriction/modification
systems!), they are among the most important enzymes used for the analysis and
recombination of DNA. In addition, they are model systems for the study of
protein-nucleic acids interactions and, because of their ubiquitous occurence,
also for the understanding of the mechanisms of evolution.
To find similar publications, click on a keyword below:
Spring 2004
: Springer
: biotechnology
: enzymology
: genetically modified organisms
: genetics
: proteins
|
|
|
|
